Even on a remote human outpost in outer space, it's never good news when aliens attack -- unless you happen to be the aliens, of course. Players can choose to guide extra-terrestrial invaders to conquer an expansive human colony, or lead the humans to defend their deep space settlement from the aggressive intruders, in this point-and-click controlled real-time strategy game developed specially for Nintendo DS. The opposing factions are designed to be equal but different, each with its own types of units, weapons, and buildings, but both relying on the same limited resources to develop their forces. Battles take place across forest, tundra, desert, and other terrain types. Command and Destroy includes a total of 24 missions, 12 for each competing faction.